DETAILED NOTES ON LIMITED EDITION EXCLUSIVE LSD CRYSTAL)

While in the LSD-certain crystal structure, the facet chain with the lid residue L209EL2 types in depth hydrophobic contacts with both of those LSD and encompassing residues in TMs III, IV, and V (Figure 4C). If the lid moved aside to show the binding pocket in simulation, quite a few of these contacts broke. We thus hypothesized that L209EL2 funct